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RECENT PAPERS FROM THE LAB
Rius-Bonet J, Macip S, Closa D, Massip-Salcedo M. Intermittent fasting as a dietary intervention with potential sexually dimorphic health benefits. Nutr Rev. 2024 May 29:nuae062. doi: 10.1093/nutrit/nuae062.
Ward JA, Romartinez-Alonso B, Kay DF,
Bellamy-Carter J, Thurairajah B, Basran J, Kwon H, Leney AC, Macip S, Roversi
P, Muskett FW, Doveston RG. Characterizing the protein-protein interaction
between MDM2 and 14-3-3s; proof of concept for small molecule stabilization.
J Biol Chem. 2024 Feb;300(2):105651. doi:
10.1016/j.jbc.2024.105651.
Chen Y, Shao X, Yang H, Ren L, Cui Y, Zhang W, Macip S, Meng X. Interferon gamma regulates a complex pro-survival signal network in chronic lymphocytic leukemia.Eur J Haematol. 2023 Apr;110(4):435-443. doi: 10.1111/ejh.13921.
Shao X, Meng X, Yang H, Wang X, Qin L, Shen G, Xi X, Zhao
H, Macip S, Chen Y. IFN-γ enhances CLL cell resistance to ABT-199
by regulating MCL-1 and BCL-2 expression via the JAK-STAT3 signaling pathway. Leuk Lymphoma. 2022 Oct 12:1-8.
Piletska E, Magumba K, Joseph L, Garcia Cruz A, Norman R, Singh
R, Tabasso AFS, Jones DJL, Macip S, Piletsky S. Molecular imprinting as
a tool for determining molecular markers: a lung cancer case. RSC Adv. 2022
Jun 15;12(28):17747-17754. doi: 10.1039/d2ra01830f.
eCollection 2022 Jun 14.
Macip S, Yuguero. Individual Freedom in the Initial Response to
Covid-19. O.Front
Public Health. 2022 Jun 3;10:765016. doi: 10.3389/fpubh.2022.765016. eCollection
2022.
Dhokia V, Moss JAY, Macip S, Fox JL. At the Crossroads of
Life and Death: The Proteins That Influence Cell Fate Decisions. Cancers
(Basel). 2022 May 31;14(11):2745. doi:
10.3390/cancers14112745.
Meng X, Cui X, Shao X, Liu Y, Xing Y, Smith V, Xiong
S, Macip S, Chen Y. poly(I:C) synergizes with proteasome inhibitors to
induce apoptosis in cervical cancer cells. Transl
Oncol. 2022 Apr;18:101362.
Dhokia V, Macip S. A master of all trades - linking retinoids to
different signalling pathways through the multi-purpose receptor STRA6.
Cell Death Discov. 2021 Nov 16;7(1):358. d
Falcicchio M, Ward JA, Chothia SY, Basran J, Mohindra
A, Macip S, Roversi P, Doveston RG. Cooperative stabilisation of 14-3-3σ
protein-protein interactions via covalent protein modification.
Chem Sci. 2021 Sep 6;12(39):12985-12992.
Poblocka M, Bassey AL, Smith VM, Falcicchio M, Manso AS,
Althubiti M, Sheng X, Kyle A, Barber R, Frigerio M, Macip S. Targeted clearance of senescent cells using an
antibody-drug conjugate against a specific membrane marker. Sci
Rep. 2021 Oct 13;11(1):20358. doi:
10.1038/s41598-021-99852-2.
Piletsky SS, Piletska E, Poblocka M, Macip S, Jones DJL, Braga
M, Cao TH, Singh R, Spivey AC, Aboagye EO, Piletsky SA. Snapshot imprinting: rapid
identification of cancer cell surface proteins and epitopes using molecularly
imprinted polymers. Nano Today 41, 101304, 2021.
Roach KM, Castells E, Dixon K, Mason S, Elliott G, Marshall H,
Poblocka MA, Macip S, Richardson M, Khalfaoui L, Bradding P. Evaluation of Pirfenidone and Nintedanib
in a Human Lung Model of Fibrogenesis. Front Pharmacol.
2021 Oct 12;12:679388. doi:
10.3389/fphar.2021.679388. eCollection 2021.
Meng X, Chen Y, Macip S, Leppard K. PML-II regulates ERK and AKT signal activation and
IFNα-induced cell death. Cell Commun
Signal. 2021 Jul 2;19(1):70. doi:
10.1186/s12964-021-00756-5.
Falcicchio M, Ward JA, Chothia SY, Basran J, Mohindra A, Macip
S, Roversi P, Doveston RG. Cooperative stabilisation of
14-3-3σ protein–protein interactions via covalent protein modification.
Chemical Science 12 (39), 12985-12992, 2021.
Rada M, Qusairy Z, Massip-Salcedo M,
Macip S.Relevance of the
Bruton Tyrosine Kinase as a Target for COVID-19 Therapy.Mol
Cancer Res. 2020 Dec 16.
Falcicchio M, Ward JA, Macip S, Doveston RG. Regulation of p53
by the 14-3-3 protein interaction network: new opportunities for drug
discovery in cancer. Cell Death Discov. 2020 Nov
16;6(1):126.
Polymeros K, Guttery DS, Hew R, Bishop R, Stannard E, Macip S, Symonds P, Moss EL. Differences in the molecular profile of endometrial cancers from British White and British South Asian women. PLoS One. 2020 Jun 10;15(6):e0233900. doi: 10.1371/journal.pone.0233900. eCollection 2020. Kaur A, Macip S, Stover CM. An Appraisal on the Value of Using
Nutraceutical Based Senolytics and Senostatics in Aging. Front Cell Dev Biol. 2020 Apr 3;8:218. doi:
10.3389/fcell.2020.00218. eCollection 2020.
Smith VM, Lomas O, Constantine D, Palmer L, Schuh AH, Bruce D,
Gonchar O, Macip S, Jayne S, Dyer MJS, Eyre TA. Dual dependence on BCL2 and
MCL1 in T-cell prolymphocytic leukemia. Blood Adv.
2020 Feb 11;4(3):525-529. doi:
10.1182/bloodadvances.2019000917.
Ekpenyong-Akiba AE, Poblocka M, Althubiti M, Rada M, Jurk D,
Germano S, Kocsis-Fodor G, Shi Y, Canales JJ, Macip S. Amelioration of
age-related brain function decline by Bruton's tyrosine kinase inhibition.
Aging Cell. 2019 Nov 17:e13079. doi:
10.1111/acel.13079.
Smith VM, Dietz A, Henz K, Bruecher D, Jackson R, Kowald L, van
Wijk SJL, Jayne S, Macip S, Fulda S, Dyer MJS, Vogler M. Specific
interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in
diffuse large B-cell lymphoma. Haematologica. 2019
Oct 10. pii: haematol.2019.220525. doi: 10.3324/haematol.2019.220525
Ekpenyong-Akiba AE, Canfarotta F, Abd B, Poblocka M, Casulleras
M, Castilla-Vallmanya L, Kocsis-Fodor G, Kelly ME, Janus J, Althubiti M,
Piletska E, Piletsky S, Macip S.
Detecting and targeting senescent cells using molecularly imprinted
nanoparticles. Nanoscale Horizons 4(3):757-768 01 May 2019
Tabasso AFS, Jones DJL, Jones GDD, Macip S. Radiotherapy-Induced
Senescence and its Effects on Responses to Treatment. Clin Oncol (R Coll Radiol). 2019 May;31(5):283-289.
Chen Y, Peubez C, Smith V, Xiong S, Kocsis-Fodor G, Kennedy B,
Wagner S, Balotis C, Jayne S, Dyer MJS, Macip S. CUDC-907 blocks multiple
pro-survival signals and abrogates microenvironment protection in CLL. J Cell
Mol Med. 2018 Oct 24. doi: 10.1111/jcmm.13935.
Rada M, Barlev N, Macip S. BTK: a two-faced effector in cancer
and tumour suppression. Cell Death Dis. 2018 Oct 18;9(11):1064. doi: 10.1038/s41419-018-1122-8.
Rada M, Barlev N, Macip S. BTK modulates p73 activity to induce
apoptosis independently of p53. Cell Death Discov.
2018 Sep 11;5:30. doi:
10.1038/s41420-018-0097-7.
Guttery DS, Blighe K, Polymeros K, Symonds RP, Macip S, Moss EL.
Racial differences in endometrial cancer molecular portraits in The Cancer
Genome Atlas. Oncotarget. 2018 Mar 30;9(24):17093-17103. doi:
10.18632/oncotarget.24907.
Chen Y, Peubez C, Jayne S, Kocsis-Fodor G, Dyer MJS, Macip S. Differential activation of pro-survival pathways in response to CD40LG/IL4 stimulation in chronic lymphocytic leukaemia cells. Br J Haematol. 2018 Apr 20. doi: 10.1111/bjh.15197.
Rada M, Althubiti M, Ekpenyong-Akiba AE, Lee KG, Lam KP,
Fedorova O, Barlev NA, Macip S. BTK blocks the inhibitory effects of MDM2 on
p53 activity. Oncotarget. 2017 Nov 20;8(63):106639-106647. doi: 10.18632/oncotarget.22543. Chen Y, Germano S,
Shelmani G, Kluczna D, Jayne S, Dyer MJS, Macip S. Paradoxical
activation of alternative pro-survival pathways determines resistance to MEK
inhibitors in chronic lymphocytic leukaemia. Br J Haematol.
2017 Aug 2. doi: 10.1111/bjh.14880. Samuel
J, Jayne S, Chen Y, Majid A, Wignall A, Wormull T,
Najeeb H, Luo J, Jones GD, Macip S,
Dyer MJ. Posttranscriptional
upregulation of p53 by reactive oxygen species in chronic lymphocytic leukemia.Cancer Res. 2016 Sep 7. pii: canres.0843.2016. Chen Y, Germano S,
Clements C, Samuel J, Shelmani G, Jayne S, Dyer MJ, Macip
S. Pro-survival
signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic
Leukaemia. Br J Haematol. 2016 Jul 29. doi: 10.1111/bjh.14285 Rada
M, Vasileva E, Lezina L, Marouco D, Antonov AV, Macip
S, Melino G, Barlev NA. Human
EHMT2/G9a activates p53 through methylation-independent mechanism.Oncogene.
2016 Jul 25. doi: 10.1038/onc.2016.258 M. Karbaschi, S. Macip, M. D.
Evans, V. Mistry, H. H. K. Abbas, M. S. Cooke, G. J. Delinassios
and A. Young. Rescue of cells from apoptosis increases DNA repair in UVB
exposed cells: implications for the DNA damage response. Toxicol.
Res. 2015 Althubiti M, Lezina L,
Carrera S, Jukes-Jones R, Giblett SM, Antonov A,
Barlev N, Saldanha GS, Pritchard C, Cain K and Macip S. Characterization of
novel markers of senescence and their prognostic potential in cancer. Cell
Death Dis. 2014 Nov 20;5:e1528. doi:
10.1038/cddis.2014.489. Carrera S, Senra J, Acosta
MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S. The role of the HIF-1
alpha transcription factor in increased cell division at physiological oxygen
tensions. PLoS One. 2014 May 16;9(5):e97938. Samuel J, Macip S, Dyer MJS.
Efficacy of vemurafenib in hairy-cell leukemia. N
Engl J Med. 2014 Jan 16;370(3):286-8. Carrera S, Cuadrado-Castano
S, Samuel J, Jones GD, Villar E, Lee SW, Macip S.Stra6,
a retinoic acid-responsive gene, participates in p53-induced apoptosis after
DNA damage. Cell Death Differ. 2013 Jul;20(7):910-9. Dyer MJS, Vogler M, Samuel J,
Jayne S, Wagner S, Pritchard C and Macip S. Precision medicines for B-cell leukaemias and lymphomas; progress and potential
pitfalls. Br J Haematol. 2013 Mar;160(6):725-33. Masgras I, Carrera S, de Verdier PJ, Brennan
P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson
IB, Macip S. Reactive oxygen species and mitochondrial sensitivity to
oxidative stress determine induction of cancer cell death by p21. J Biol
Chem. 2012 Mar 23;287(13):9845-54. Carrera S, de Verdier PJ,
Khan Z, Zhao B, Mahale A, Bowman KJ, Zainol M, Jones GD, Lee SW, Aaronson SA,
Macip S. Protection of cells in physiological oxygen tensions against DNA
damage-induced apoptosis.J
Biol Chem. 2010 Mar 12. PREVIOUS RELEVANT PAPERS Muñoz-Fontela C, Macip S,
Martínez-Sobrido L, Brown L, Ashour J,
García-Sastre A, Lee SW, Aaronson SA. Transcriptional role of p53 in
interferon-mediated antiviral immunity.J
Exp Med. 2008 Aug 4;205(8):1929-38. Battini L, Macip S, Fedorova E, Dikman S, Somlo S, Montagna C,
Gusella GL. Loss of polycystin-1 causes centrosome amplification and genomic instability.Hum Mol Genet. 2008
Sep 15;17(18):2819-33. Tan MC, Battini
L, TuyamaAC, Macip S, Melendi
GA, Horga MA.Characterization
of human metapneumovirus infection of myeloid dendritic cells.Virology.
2007 Jan 5;357(1):1-9. Battini L, Fedorova E, Macip S, Li X,
Wilson PD, Gusella GL. Stable knockdown of polycystin-1 confers
integrin-alpha2beta1-mediated anoikis resistance. J
Am Soc Nephrol. 2006 Nov;17(11):3049-58. Macip,S. Kosoy,A. Lee,SW. O'Connell,MJ. Aaronson,S.A Role of a
Chk1-dependent G2 checkpoint in protecting p53-null cancer cells from
oxidative stress.Oncogene, 2006 (25): 6037-6047. Horga,MA. Macip,S. Tuyama,AC. Tan, MC. Gusella,GL.Human
parainfluenza virus 3 neuraminidase activity contributes to dendritic cell maturation.Viral Immunol. 2005;18(3):523-33. Ongusaha,PP. Kwak,JC. Zwible,AJ. Macip,S. Higashiyama,S. Taniguchi, N. Fang,L.
Lee,SW.HB-EGF is a potent inducer of tumor growth and angiogenesis.Cancer
Res. 2004 Aug 1;64(15):5283-90. Ohtsuka,T. Ryu,H. Minamishima,Y.A. Macip,S.
Sagara,J. Aaronson,S.A.
and Lee,S.W.ASC functions as an adaptor for Bax and regulates a p53-Bax mitochondrial pathway of apoptosis.Nat Cell Biol. 2004 Feb;6(2):121-8. Macip,S. Igarashi,M.
Berggren,P. Lee,S.W. and Aaronson,S.A.Influence of induced ROS levels in
determining p53-mediated growth arrest or apoptosis.Mol
Cell Biol, 23(23):8576-85, 2003 Macip,S. Igarashi,M.
Fang,L Chen,A Pan,ZQ. Lee,S. W. and Aaronson,S.A.
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence.EMBO Journal, 21(9):2180-88, 2002 |