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| RECENT PAPERS FROM THE LAB
Chen Y, Shao X, Yang H, Ren L, Cui Y, Zhang W, Macip S, Meng X. Interferon gamma regulates a complex pro-survival signal network in chronic lymphocytic leukemia.Eur J Haematol. 2023 Apr;110(4):435-443. doi: 10.1111/ejh.13921. Shao X, Meng X, Yang H, Wang X, Qin L, Shen G, Xi X, Zhao H, Macip S, Chen Y. IFN-γ enhances CLL cell resistance to ABT-199 by regulating MCL-1 and BCL-2 expression via the JAK-STAT3 signaling pathway. Leuk Lymphoma. 2022 Oct 12:1-8. Piletska E, Magumba K, Joseph L, Garcia Cruz A, Norman R, Singh R, Tabasso AFS, Jones DJL, Macip S, Piletsky S. Molecular imprinting as a tool for determining molecular markers: a lung cancer case. RSC Adv. 2022 Jun 15;12(28):17747-17754. doi: 10.1039/d2ra01830f. eCollection 2022 Jun 14. Macip S, Yuguero. Individual Freedom in the Initial Response to Covid-19. O.Front Public Health. 2022 Jun 3;10:765016. doi: 10.3389/fpubh.2022.765016. eCollection 2022. Dhokia V, Moss JAY, Macip S, Fox JL. At the Crossroads of Life and Death: The Proteins That Influence Cell Fate Decisions. Cancers (Basel). 2022 May 31;14(11):2745. doi: 10.3390/cancers14112745. Meng X, Cui X, Shao X, Liu Y, Xing Y, Smith V, Xiong S, Macip S, Chen Y. poly(I:C) synergizes with proteasome inhibitors to induce apoptosis in cervical cancer cells. Transl Oncol. 2022 Apr;18:101362. Dhokia V, Macip S. A master of all trades - linking retinoids to different signalling pathways through the multi-purpose receptor STRA6. Cell Death Discov. 2021 Nov 16;7(1):358. d Falcicchio M, Ward JA, Chothia SY, Basran J, Mohindra A, Macip S, Roversi P, Doveston RG. Cooperative stabilisation of 14-3-3σ protein-protein interactions via covalent protein modification. Chem Sci. 2021 Sep 6;12(39):12985-12992. Poblocka M, Bassey AL, Smith VM, Falcicchio M, Manso AS, Althubiti M, Sheng X, Kyle A, Barber R, Frigerio M, Macip S. Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker. Sci Rep. 2021 Oct 13;11(1):20358. doi: 10.1038/s41598-021-99852-2. Piletsky SS, Piletska E, Poblocka M, Macip S, Jones DJL, Braga M, Cao TH, Singh R, Spivey AC, Aboagye EO, Piletsky SA. Snapshot imprinting: rapid identification of cancer cell surface proteins and epitopes using molecularly imprinted polymers. Nano Today 41, 101304, 2021. Roach KM, Castells E, Dixon K, Mason S, Elliott G, Marshall H, Poblocka MA, Macip S, Richardson M, Khalfaoui L, Bradding P. Evaluation of Pirfenidone and Nintedanib in a Human Lung Model of Fibrogenesis. Front Pharmacol. 2021 Oct 12;12:679388. doi: 10.3389/fphar.2021.679388. eCollection 2021. Meng X, Chen Y, Macip S, Leppard K. PML-II regulates ERK and AKT signal activation and IFNα-induced cell death. Cell Commun Signal. 2021 Jul 2;19(1):70. doi: 10.1186/s12964-021-00756-5. Falcicchio M, Ward JA, Chothia SY, Basran J, Mohindra A, Macip S, Roversi P, Doveston RG. Cooperative stabilisation of 14-3-3σ protein–protein interactions via covalent protein modification. Chemical Science 12 (39), 12985-12992, 2021.
Rada M, Qusairy Z, Massip-Salcedo M, Macip S. Falcicchio M, Ward JA, Macip S, Doveston RG.
Regulation of p53 by the 14-3-3 protein interaction network: new
opportunities for drug discovery in cancer. Cell Death Discov. 2020
Nov 16;6(1):126. Polymeros K, Guttery DS, Hew R, Bishop R, Stannard E, Macip S, Symonds P, Moss EL. Differences in the molecular profile of endometrial cancers from British White and British South Asian women. PLoS One. 2020 Jun 10;15(6):e0233900. doi: 10.1371/journal.pone.0233900. eCollection 2020. Kaur A, Macip S, Stover CM. An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging. Front Cell Dev Biol. 2020 Apr 3;8:218. doi: 10.3389/fcell.2020.00218. eCollection 2020. Smith VM, Lomas O, Constantine D, Palmer L, Schuh AH, Bruce D, Gonchar O, Macip S, Jayne S, Dyer MJS, Eyre TA. Dual dependence on BCL2 and MCL1 in T-cell prolymphocytic leukemia. Blood Adv. 2020 Feb 11;4(3):525-529. doi: 10.1182/bloodadvances.2019000917. Ekpenyong-Akiba AE, Poblocka M, Althubiti M, Rada
M, Jurk D, Germano S, Kocsis-Fodor G, Shi Y, Canales JJ, Macip S.
Amelioration of age-related brain function decline by Bruton's
tyrosine kinase inhibition. Aging Cell. 2019 Nov 17:e13079. doi:
10.1111/acel.13079. Smith VM, Dietz A, Henz K, Bruecher D, Jackson R,
Kowald L, van Wijk SJL, Jayne S, Macip S, Fulda S, Dyer MJS, Vogler M.
Specific interactions of BCL-2 family proteins mediate sensitivity to
BH3-mimetics in diffuse large B-cell lymphoma. Haematologica. 2019 Oct
10. pii: haematol.2019.220525. doi: 10.3324/haematol.2019.220525 Ekpenyong-Akiba AE, Canfarotta F, Abd B, Poblocka
M, Casulleras M, Castilla-Vallmanya L, Kocsis-Fodor G, Kelly ME, Janus
J, Althubiti M, Piletska E, Piletsky S, Macip S. Detecting and targeting senescent cells using
molecularly imprinted nanoparticles. Nanoscale Horizons 4(3):757-768
01 May 2019 Tabasso AFS, Jones DJL, Jones GDD, Macip S.
Radiotherapy-Induced Senescence and its Effects on Responses to
Treatment. Clin Oncol (R Coll Radiol). 2019 May;31(5):283-289. Chen Y, Peubez C, Smith V, Xiong S, Kocsis-Fodor
G, Kennedy B, Wagner S, Balotis C, Jayne S, Dyer MJS, Macip S.
CUDC-907 blocks multiple pro-survival signals and abrogates
microenvironment protection in CLL. J Cell Mol Med. 2018 Oct 24. doi:
10.1111/jcmm.13935. Rada M, Barlev N, Macip S. BTK: a two-faced
effector in cancer and tumour suppression. Cell Death Dis. 2018 Oct
18;9(11):1064. doi: 10.1038/s41419-018-1122-8. Rada M, Barlev N, Macip S. BTK modulates p73
activity to induce apoptosis independently of p53. Cell Death Discov.
2018 Sep 11;5:30. doi: 10.1038/s41420-018-0097-7
Guttery DS, Blighe K, Polymeros K, Symonds RP, Macip S, Moss EL.
Racial differences in endometrial cancer molecular portraits in The
Cancer Genome Atlas. Oncotarget. 2018 Mar 30;9(24):17093-17103. doi:
10.18632/oncotarget.24907 Rada M, Althubiti M, Ekpenyong-Akiba AE, Lee KG,
Lam KP, Fedorova O, Barlev NA, Macip S. BTK blocks the inhibitory
effects of MDM2 on p53 activity. Oncotarget. 2017 Nov
20;8(63):106639-106647. doi: 10.18632/oncotarget.22543.
Chen Y, Germano S, Shelmani
G, Kluczna D, Jayne S, Dyer MJS, Macip S. Paradoxical activation of
alternative pro-survival pathways determines resistance to MEK
inhibitors in chronic lymphocytic leukaemia. Br J Haematol. 2017
Aug 2. doi: 10.1111/bjh.14880.
Samuel J, Jayne S, Chen Y, Majid A, Wignall A, Wormull T, Najeeb H, Luo J, Jones GD, Macip S, Dyer MJ. Posttranscriptional upregulation of p53 by reactive oxygen species in chronic lymphocytic leukemia.Cancer Res. 2016 Sep 7. pii: canres.0843.2016. Chen Y, Germano S, Clements C, Samuel J, Shelmani G, Jayne S, Dyer MJ, Macip S. Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia. Br J Haematol. 2016 Jul 29. doi: 10.1111/bjh.14285
Rada M, Vasileva E, Lezina L, Marouco D, Antonov AV, Macip S, Melino G, Barlev NA. Human EHMT2/G9a activates p53 through methylation-independent mechanism.Oncogene. 2016 Jul 25. doi: 10.1038/onc.2016.258 M. Karbaschi, S. Macip, M. D. Evans, V. Mistry, H. H. K. Abbas, M. S. Cooke, G. J. Delinassios and A. Young. Rescue of cells from apoptosis increases DNA repair in UVB exposed cells: implications for the DNA damage response. Toxicol. Res. 2015 Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard C, Cain K and Macip S. Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. 2014 Nov 20;5:e1528. doi: 10.1038/cddis.2014.489. Carrera S, Senra J, Acosta MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S. The role of the HIF-1 alpha transcription factor in increased cell division at physiological oxygen tensions. PLoS One. 2014 May 16;9(5):e97938. Samuel J, Macip S, Dyer MJS. Efficacy of vemurafenib in hairy-cell leukemia. N Engl J Med. 2014 Jan 16;370(3):286-8. Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW, Macip S.Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ. 2013 Jul;20(7):910-9. Dyer MJS, Vogler M, Samuel J, Jayne S, Wagner S, Pritchard C and Macip S. Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls. Br J Haematol. 2013 Mar;160(6):725-33. Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. 2012 Mar 23;287(13):9845-54. Carrera S, de Verdier PJ, Khan Z, Zhao B, Mahale A, Bowman KJ, Zainol M, Jones GD, Lee SW, Aaronson SA, Macip S. Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis.J Biol Chem. 2010 Mar 12.
PREVIOUS RELEVANT PAPERS Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA. Transcriptional role of p53 in interferon-mediated antiviral immunity.J Exp Med. 2008 Aug 4;205(8):1929-38. Battini L, Macip S, Fedorova E, Dikman S, Somlo S, Montagna C, Gusella GL. Loss of polycystin-1 causes centrosome amplification and genomic instability.Hum Mol Genet. 2008 Sep 15;17(18):2819-33. Tan MC, Battini L, TuyamaAC, Macip S, Melendi GA, Horga MA.Characterization of human metapneumovirus infection of myeloid dendritic cells.Virology. 2007 Jan 5;357(1):1-9. Battini L, Fedorova E, Macip S, Li X, Wilson PD, Gusella GL. Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance. J Am Soc Nephrol. 2006 Nov;17(11):3049-58. Macip,S. Kosoy,A. Lee,SW. O'Connell,MJ. Aaronson,S.A Role of a Chk1-dependent G2 checkpoint in protecting p53-null cancer cells from oxidative stress.Oncogene, 2006 (25): 6037-6047. Horga,MA. Macip,S. Tuyama,AC. Tan, MC. Gusella,GL.Human parainfluenza virus 3 neuraminidase activity contributes to dendritic cell maturation.Viral Immunol. 2005;18(3):523-33. Ongusaha,PP. Kwak,JC. Zwible,AJ. Macip,S. Higashiyama,S. Taniguchi, N. Fang,L. Lee,SW.HB-EGF is a potent inducer of tumor growth and angiogenesis.Cancer Res. 2004 Aug 1;64(15):5283-90. Ohtsuka,T. Ryu,H. Minamishima,Y.A. Macip,S. Sagara,J. Aaronson,S.A. and Lee,S.W.ASC functions as an adaptor for Bax and regulates a p53-Bax mitochondrial pathway of apoptosis.Nat Cell Biol. 2004 Feb;6(2):121-8. Macip,S. Igarashi,M. Berggren,P. Lee,S.W. and Aaronson,S.A.Influence of induced ROS levels in determining p53-mediated growth arrest or apoptosis.Mol Cell Biol, 23(23):8576-85, 2003 Macip,S. Igarashi,M. Fang,L Chen,A Pan,ZQ. Lee,S. W. and Aaronson,S.A. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence.EMBO Journal, 21(9):2180-88, 2002 |