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RECENT PAPERS FROM THE LAB

Althubiti M, Macip S. Detection of Senescent Cells by Extracellular Markers Using a Flow Cytometry-Based Approach. Methods Mol Biol. 2017;1534:147-153.

Althubiti M, Rada M, Samuel J, Escorsa JM, Najeeb H, Lee KG, Lam KP, Jones GD, Barlev NA, Macip S.
BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses.Cancer Res. 2016 Sep 15;76(18):5405-14. doi: 10.1158/0008-5472.CAN-16-0690. Epub 2016 Jul 26.

 

Samuel J, Jayne S, Chen Y, Majid A, Wignall A, Wormull T, Najeeb H, Luo J, Jones GD, Macip S, Dyer MJ. Posttranscriptional upregulation of p53 by reactive oxygen species in chronic lymphocytic leukemia.Cancer Res. 2016 Sep 7. pii: canres.0843.2016.

 

Chen Y, Germano S, Clements C, Samuel J, Shelmani G, Jayne S, Dyer MJ, Macip S. Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia. Br J Haematol. 2016 Jul 29. doi: 10.1111/bjh.14285

 

Rada M, Vasileva E, Lezina L, Marouco D, Antonov AV, Macip S, Melino G, Barlev NA. Human EHMT2/G9a activates p53 through methylation-independent mechanism.Oncogene. 2016 Jul 25. doi: 10.1038/onc.2016.258

M. Karbaschi, S. Macip, M. D. Evans, V. Mistry, H. H. K. Abbas, M. S. Cooke, G. J. Delinassios and A. Young. Rescue of cells from apoptosis increases DNA repair in UVB exposed cells: implications for the DNA damage response. Toxicol. Res. 2015

Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard C, Cain K and Macip S. Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. 2014 Nov 20;5:e1528. doi: 10.1038/cddis.2014.489.

Carrera S, Senra J, Acosta MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S. The role of the HIF-1 alpha transcription factor in increased cell division at physiological oxygen tensions. PLoS One. 2014 May 16;9(5):e97938.

Samuel J, Macip S, Dyer MJS. Efficacy of vemurafenib in hairy-cell leukemia. N Engl J Med. 2014 Jan 16;370(3):286-8.

Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW, Macip S.Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ. 2013 Jul;20(7):910-9.

Dyer MJS, Vogler M, Samuel J, Jayne S, Wagner S, Pritchard C and Macip S. Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls. Br J Haematol. 2013 Mar;160(6):725-33.

Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. 2012 Mar 23;287(13):9845-54.

Carrera S, de Verdier PJ, Khan Z, Zhao B, Mahale A, Bowman KJ, Zainol M, Jones GD, Lee SW, Aaronson SA, Macip S. Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis.J Biol Chem. 2010 Mar 12.

 

PREVIOUS RELEVANT PAPERS

Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA. Transcriptional role of p53 in interferon-mediated antiviral immunity.J Exp Med. 2008 Aug 4;205(8):1929-38.

Battini L, Macip S, Fedorova E, Dikman S, Somlo S, Montagna C, Gusella GL. Loss of polycystin-1 causes centrosome amplification and genomic instability.Hum Mol Genet. 2008 Sep 15;17(18):2819-33.

Tan MC, Battini L, TuyamaAC, Macip S, Melendi GA, Horga MA.Characterization of human metapneumovirus infection of myeloid dendritic cells.Virology. 2007 Jan 5;357(1):1-9.

Battini L, Fedorova E, Macip S, Li X, Wilson PD, Gusella GL. Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance. J Am Soc Nephrol. 2006 Nov;17(11):3049-58.

Macip,S. Kosoy,A. Lee,SW. O'Connell,MJ. Aaronson,S.A Role of a Chk1-dependent G2 checkpoint in protecting p53-null cancer cells from oxidative stress.Oncogene, 2006 (25): 6037-6047.

Horga,MA. Macip,S. Tuyama,AC. Tan, MC. Gusella,GL.Human parainfluenza virus 3 neuraminidase activity contributes to dendritic cell maturation.Viral Immunol. 2005;18(3):523-33.

Ongusaha,PP. Kwak,JC. Zwible,AJ. Macip,S. Higashiyama,S. Taniguchi, N. Fang,L. Lee,SW.HB-EGF is a potent inducer of tumor growth and angiogenesis.Cancer Res. 2004 Aug 1;64(15):5283-90.

Ohtsuka,T. Ryu,H. Minamishima,Y.A. Macip,S. Sagara,J. Aaronson,S.A. and Lee,S.W.ASC functions as an adaptor for Bax and regulates a p53-Bax mitochondrial pathway of apoptosis.Nat Cell Biol. 2004 Feb;6(2):121-8.

Macip,S. Igarashi,M. Berggren,P. Lee,S.W. and Aaronson,S.A.Influence of induced ROS levels in determining p53-mediated growth arrest or apoptosis.Mol Cell Biol, 23(23):8576-85, 2003

Macip,S. Igarashi,M. Fang,L Chen,A Pan,ZQ. Lee,S. W. and Aaronson,S.A. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence.EMBO Journal, 21(9):2180-88, 2002